848061-21-2Relevant academic research and scientific papers
Enyne Amides to Fused Pyridones: Scope and Limitations
Labadie, Sharada S.,Thai, Karine,Grandner, Jessica M.,Liu, Yanzhou,Parr, Brendan T.
, p. 14177 - 14191 (2021/08/24)
Herein we present an investigation into the scope and mechanism for the synthesis of cyclopentyl and heterocyclic fused pyridones from the corresponding enyne amides. In the presence of a secondary amine, cyclization proceeds smoothly to form 5,6-bicyclic
Regio- and stereoselective synthesis of cyclic imidates via electrophilic cyclization of 2-(1-alkynyl)benzamides. A correction
Mehta, Saurabh,Yao, Tuanli,Larock, Richard C.
supporting information, p. 10938 - 10944 (2013/02/22)
The electrophilic cyclization of 2-(1-alkynyl)benzamides affords high yields of cyclic imidates, instead of the previously reported isoindolin-1-ones, where cyclization proceeds on the oxygen of the carbonyl group rather than the nitrogen of the amide fun
Regio- and stereoselective synthesis of isoindolin-1-ones via electrophilic cyclization
Yao, Tuanli,Larock, Richard C.
, p. 1432 - 1437 (2007/10/03)
(Chemical Equation Presented) A variety of substituted isoindolin-1-ones are readily prepared in good to excellent yields under very mild reaction conditions by the reaction of o-(1-alkynyl)benzamides with ICl, I2, and NBS. In a few cases, subs
