848095-02-3Relevant academic research and scientific papers
Synthetic method of 2-(4-fluorophenyl) thiophene
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Paragraph 0047; 0048; 0049, (2017/02/24)
The invention discloses a synthetic method of 2-(4-fluorophenyl) thiophene. The synthetic method comprises the following steps: 1), performing Vilsmeier-Haack reaction on 4-fluoroacetophenone under the action of solid triphosgene and N,N-dimethylfomamide to obtain 2-chloro-2-(4-fluorophenyl) acetaldehyde; 2), performing ring-closing reaction between 2-chloro-2-(4-fluorophenyl) acetaldehyde and ethyl thioglycolate under the action of alkali to obtain 5-(4-fluorophenyl) thiophene-2-carboxylic acid ethyl ester; 3), performing esterolysis on 5-(4-fluorophenyl) thiophene-2-carboxylic acid ethyl ester under the action of alkali to obtain 5-(4-fluorophenyl) thiophene-2-formic acid; and 4), preparing 2-(4-fluorophenyl) thiophene from 5-(4-fluorophenyl) thiophene-2-formic acid under the catalysis of copper powder. The invention provides a synthetic method with low-price and easily-available raw materials and mild reaction conditions for synthesis of 2-(4-fluorophenyl) thiophene, the entire reaction has no special requirements on equipment and reaction conditions, and the yield of a product is relatively high; and the synthetic method is simple and convenient to operate, can ensure the safety of operators, and has a good market prospect.
Base catalyzed reaction of ethyl thioglycolate with β-aryl-β-(methylthio) acroleins: A general method for the synthesis of 2-carbethoxy-5-substituted/4,5-annulated thiophenes in high overall yields
Byre Gowda,Pradeepa Kumara,Ramesh,Sadashiva,Junjappa
supporting information, p. 928 - 931 (2016/02/05)
(Methylthio) acroleins 1a-m were shown to be stable unlike their counterpart the chloroacroleins and their efficacy as 1,3-dielectrophilic properties have now been examined successfully in this work. They are shown to react with ethyl thioglycolate in the
NOVEL NEUROTRYPSIN INHIBITORS
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Page/Page column 27, (2012/05/20)
The invention relates to novel acylamino-hydroxy-benzamides of formula (I), wherein R1 is phenyl substituted by phenyl, phenoxy, phenylamino or heteroaryl, all optionally further substituted; bicyclic aryl, monocyclic heteroaryl substituted by
Microwave assisted synthesis of 5-arylthiophene-2-carboxylates
Jagath Reddy,Latha,Sailaja,Pallavi,Srinivasa Rao
, p. 411 - 414 (2007/10/03)
A simple and rapid method for the synthesis of 5-Aryl-thiophene-2- carboxylates 3 has been developed by the condensation of β-chlorovinyl aldehydes 1 with mercaptoacetic acid esters 2 under microwave irradiation conditions.
