84812-15-7Relevant academic research and scientific papers
Benzazepine Dicarboxamide Compounds
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, (2016/09/26)
This invention relates to novel benzazepine dicarboxamide compounds of the formula wherein R1 to R4 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are TLR agonists and may therefore be useful as medicaments for the treatment of diseases such as cancer, autoimmune diseases, inflammation, sepsis, allergy, asthma, graft rejection, graft-versus-host disease, immunodeficiencies, and infectious diseases.
Role of the Through-Space 2p-3d Overlap Effect in the Wittig Reaction
McEwen, William E.,Cooney, John V.
, p. 983 - 987 (2007/10/02)
Reactions of the ylide derived from triphenyl(3-phthalimidopropyl)phosphonium bromide with aromatic aldehydes have been reported to give exclusively the Z alkenes.On the basis of the Bestmann mechanism for the Wittig reaction, and also because of the fact that a 2,6-dimethoxyphenyl group enters into a strong through-space 2p-3d overlap interaction with an adjacent phosphonio group, we postulated that the reactions of the ylide derived from (2,6-dimethoxyphenyl)diphenyl(3-phthalimidopropyl)phosphonium bromide with aromatic aldehydes would give substantial ratios of E:Z alkenes.This proved to be the case.
