848139-79-7

Upstream product

• 144347-32-0 4-benzyloxy-3-chloroaniline 
• 848133-76-6 7-ethoxy-6-acetylamino-4-chloro-quinoline-3-carbonitrile 

Downstream Products

• 544417-29-0 6-amino-4-(4-benzyloxy-3-chlorophenylamino)-7-ethoxyquinoline-3-carbonitrile 
• 915942-05-1 6-amino-4-[4-(benzyloxy)-3-chloroanilino]-3-cyano-7-ethoxyquinoline hydrochloride 

Relevant academic research and scientific papers

COMPOSITION AND METHODS FOR INHIBITING MAMMALIAN STERILE 20-LIKE KINASE 1

Disclosed herein are compounds, compositions, and methods of their use for the treatment of diabetes.

Methods of synthesizing substituted 3-cyanoquinolines and intermediates thereof

The invention is directed to methods of making substituted 3-cyanoquinolines, including compounds according to the following formula: The methods are amenable to large scale manufacture, avoid the use of chromatographic separations, and provide stable, high purity product more efficiently than in the prior art.

Protein tyrosine kinase enzyme inhibitors

This invention provides compounds of formula 1, having the structure wherein R1, R2, R3, R4, and R5 are described within the specification.

SUBSTITUTED QUINOLINES AS PROTEIN TYROSINE KINASE ENZYME INHIBITORS

This invention provides compounds of formula (I), having the structure wherein R1, R2, R3 are described within the specification. The compounds act as anti-cancer agents by inhibition of HER-2 and EGFR.