848141-11-7 Usage
Uses
Used in Pharmaceutical Industry:
AZD 9668 is used as a therapeutic agent for the treatment of inflammatory and lung diseases. Its ability to inhibit neutrophil elastase activity in zymosan-stimulated isolated whole blood and cell-associated assays (IC50s = 46 and 48 nM, respectively) makes it a potential candidate for managing conditions associated with excessive neutrophil elastase activity.
Used in Inflammation Management:
AZD 9668 is used as an anti-inflammatory agent, as it decreases the number of neutrophils in bronchoalveolar lavage fluid (BALF) in a mouse model of smoke-induced airway inflammation when administered at a dose of 6 mg/kg. This suggests its potential use in treating inflammatory conditions in the respiratory system.
Used in Chronic Obstructive Pulmonary Disease (COPD) Treatment:
AZD 9668 is used as a disease-modifying agent for the treatment of chronic smoke-induced inflammation and emphysema. It has been shown to prevent airspace enlargement and small airway remodeling in a guinea pig model, indicating its potential to slow down or halt the progression of COPD.
references
[1] stevens t, ekholm k, gr?nse m, et al. azd9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase. journal of pharmacology and experimental therapeutics, 2011, 339(1): 313-320.
Check Digit Verification of cas no
The CAS Registry Mumber 848141-11-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,8,1,4 and 1 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 848141-11:
(8*8)+(7*4)+(6*8)+(5*1)+(4*4)+(3*1)+(2*1)+(1*1)=167
167 % 10 = 7
So 848141-11-7 is a valid CAS Registry Number.
848141-11-7Relevant academic research and scientific papers
NOVEL SALT 628
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Page/Page column 21-22, (2010/09/05)
6-Methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-{[5-(methylsulfonyl)pyridin-2-yl]methyl}-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide 4-methylbenzenesulfonate and a novel crystalline form thereof are disclosed together with processes for preparing such salt and form, pharmaceutical compositions comprising such a salt and form, and the methods of treatment using such a salt and form.
2-PYRIDONE DERIVATIVES AS NEUTROPHIL ELASTASE INHIBITORS AND THEIR USE
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Page/Page column 86-87, (2010/02/11)
There are provided novel compounds of formula (I), wherein R1, R2, R4, R5, G1, G2, L, Y and n are as defined in the Specification and optical isomers, racemates and tautomers thereof, and p
