848149-05-3Relevant academic research and scientific papers
Identification of nonabsorbable inhibitors of the scavenger receptor-BI (SR-BI) for tissue-specific administration
Sparks, Steven M.,Zhou, Huiqiang,Generaux, Claudia,Harston, Lindsey,Moncol, David,Jayawickreme, Channa,Parham, Janet,Condreay, Patrick,Rimele, Thomas
, p. 1901 - 1904 (2016/04/05)
The identification of a low-permeability scavenger receptor BI (SR-BI) inhibitor starting from the ITX-5061 template is described. Structure-activity and structure-permeability relationships were assessed for analogs leading to the identification of compound 8 as a potent and nonabsorbable SR-BI inhibitor.
