848172-01-0Relevant academic research and scientific papers
Stereochemistry of N-Benzoyl-5-substituted-1-benzazepines Revisited: Synthesis of the Conformationally Biased Derivatives and Revision of the Reported Structure
Tabata, Hidetsugu,Yoneda, Tetsuya,Tasaka, Tomohiko,Ito, Shigekazu,Oshitari, Tetsuta,Takahashi, Hideyo,Natsugari, Hideaki
, p. 3136 - 3148 (2016/05/19)
The syn (aR?,5R?) and anti (aS?,5R?) diastereomers of N-benzoyl-C5-substituted-1-benzazepines originating in the chiralities at C5 and the Ar-N(C=O) axis were first stereoselectively synthesized by biasing the conformation with a substituent at C6 and C9, respectively. Detailed examination of the stereochemistry (i.e., conformation and configuration) of these N-benzoyl-1-benzazepines by X-ray crystallographic analysis, VT NMR, and DFT calculations revealed new physicochemical aspects of these heterocycles including revision of the stereochemistry previously reported.
Conformation analyses, dynamic behavior and amide bond distortions of medium-sized heterocycles. 1. Partially and fully reduced 1-benzazepines
Qadir, Maryiam,Cobb, Jonathan,Sheldrake, Peter W.,Whittall, Neil,White, Andrew J. P.,King, Kuok Hii,Horton, Peter N.,Hursthouse, Michael B.
, p. 1545 - 1551 (2007/10/03)
(Chemical Equation Presented) Five 1-benzazepine heterocycles were synthesized by utilizing transition-metal-catalyzed processes in key bond-forming steps. exo-Methylene and methyl substituents were introduced at position 5, as well as a unit of unsaturat
