848194-75-2

Basic information

• Product Name: Carbamic acid, [(2-chlorophenyl)methylene]-, 1,1-dimethylethyl ester
• CAS NO: 848194-75-2
• Molecular Formula: C12H14ClNO2
• Molecular Weight: 239.702
• Mol File: 848194-75-2.mol

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(2-chlorophenyl)methylene]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(2-chlorophenyl)methylene]-, 1,1-dimethylethyl ester(848194-75-2)
• EPA Substance Registry System: Carbamic acid, [(2-chlorophenyl)methylene]-, 1,1-dimethylethyl ester(848194-75-2)

Safety Data

• Hazardous Substances Data: 848194-75-2(Hazardous Substances Data)

Upstream product

• 1071051-67-6 C₁₉H₂₂ClNO₄S 
• 4248-19-5 tert-butyl carbazate 
• 89-98-5 2-chloro-benzaldehyde 
• 1140969-70-5 N-(tert-butoxycarbonyl)-α-(phenylsulfonyl)-2-chlorobenzylamine 

Downstream Products

• 1023695-49-9 1-(o-chlorophenyl)-2-nitroethylcarbamic acid t-butyl ester 
• 1402850-86-5 tert-butyl (2S,3R)-6-methyl-2-(2-methylphenyl)-3-nitro-3,4-dihydropyridine-1(2H)-carboxylate 

Relevant articles and documents

Enantioselective Construction of Sulfur-Containing Tetrasubstituted Stereocenters via Asymmetric Functionalizations of α-Sulfanyl Cyclic Ketones

Asymmetric functionalizations of α-sulfanyl cyclic ketones were realized via chiral phosphoric acid catalyzed enantioselective addition reactions with aldimines, azodicarboxylates and allenamides. A series of chiral organosulfur compounds possessing sulfur-containing tetrasubstituted stereocenters were accessed via these methods, with excellent regioselectivities and high stereoselectivities. (Figure presented.).

Silver-Catalyzed Enantioselective Mannich Reaction of Diazoacetate Esters with N-Boc Aldimines

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Direct enantioselective Mannich reactions of α-azido cyclic ketones: Asymmetric construction of chiral azides possessing an α-quaternary stereocenter

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Highly efficient and enantioselective copper(I)-catalyzed pinacolboryl addition of N-Boc-imines is reported. By using a single chiral sulfoxide-(dialkyl)phosphine (SOP) ligand, both enantiomeric isomers of α-amino boronic esters were obtained through an achiral counteranion switch.

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The diastereo- and enantioselective reductive coupling of vinylazaarenes with N-Boc aldimines is described. The reactions proceed using chiral copper-bisphosphine complexes in the presence of TMDS as a hydride source to give reductive coupling products in moderate to high enantioselectivities.

Construction of chiral quaternary carbon center via catalytic asymmetric aza-Henry reaction with α-substituted nitroacetates

The catalytic enantioselective aza-Henry reaction of N-Boc aldimines 2 and 2-nitropropionic acid ethyl ester 3 in the mixed solvents of toluene-saturated brine (10:1) was catalyzed by cinchona quaternary ammonium salts to form a new quaternary carbon center. High yields (up to 90%), and excellent enantioselectivities (up to 99% ee) and diastereoselectivity ratio (up to 22:1) were successfully obtained with mild conditions. This journal is the Partner Organisations 2014.

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Yb(OTf)3/iPr-pybox (3b) immobilized on a self-assembled organic-inorganic hybrid silica with ionic liquid phase (SAILP) (Catalyst A) behaves as an efficient and recyclable catalyst in the enantioselective Mannich reaction of malonate esters wit

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