848210-41-3Relevant academic research and scientific papers
Synthesis and biological activity of N-substituted aminocarbonyl-1,3- dioxolanes as VLA-4 antagonists
Rehman, Abdul,Soni, Ajay,Naik, Keshav,Nair, Sreeji,Palle, Venkata P.,Dastidar, Sunanda,Ray, Abhijit,Alam,Salman, Mohammad,Cliffe, Ian A.,Sattigeri, Viswajanani
scheme or table, p. 5514 - 5520 (2011/01/12)
A novel set of compounds with a 1,3-dioxolane ring which acts as a proline bioisostere have been successfully designed as VLA-4 receptor antagonists. Compounds (18e), (28j), and (35g) were shown to have high receptor affinities.
DIOXOLANE DERIVATIVES AS CELL ADHESION INHIBITORS
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Page/Page column 67, (2010/02/11)
The present invention relates to dioxolane derivatives as cell adhesion inhibitors. These compounds can be useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies, including inflammatory and autoimmune diseases such as
