848253-11-2Relevant academic research and scientific papers
Design of HIV-1 protease inhibitors active on multidrug-resistant virus
Surleraux, Dominique L. N. G.,De Kock, Herman A.,Verschueren, Wim G.,Pille, Geert M. E.,Maes, Louis J. R.,Peeters, Anik,Vendeville, Sandrine,De Meyer, Sandra,Azijn, Hilde,Pauwels, Rudi,De Bethune, Marie-Pierre,King, Nancy M.,Prabu-Jeyabalan, Moses,Schiffer, Celia A.,Wigerinck, Piet B. T. P.
, p. 1965 - 1973 (2007/10/03)
On the basis of structural data gathered during our ongoing HIV-1 protease inhibitors program, from which our clinical candidate TMC114 9 was selected, we have discovered new series of fused heteroaromatic sulfonamides. The further extension into the P2′
