84827-54-3Relevant academic research and scientific papers
Intramolecular friedel-crafts-type reactions involving N-acyliminium ions derived from glycine templates
Sanchez,Ramos,Avendano
, p. 5731 - 5735 (2007/10/03)
Enantiomerically pure 4-substituted 2-aralkyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-diones (1b-m) in which the alkyl chain is (CH2)n, n = 1-3, behave as glycine templates giving by treatment with [hydroxy(tosyloxy)iodo]benzene in ethyl acetate cis-1-tosyloxy derivatives. When these compounds contain electron-rich aryl substituents with n = 2, they spontaneously cyclize through intramolecular Friedel-Crafts-type diastereoselective reactions to give penta- or hexacyclic compounds. Otherwise, they give by solvolysis cis-1-alkoxy derivatives, which in a second step, may be cyclized in acid if n = 2, 3. All these reactions must occur through N-acyliminium species in SN1-like mechanisms. 1-Alkoxy-2-arylmethyl derivatives are reluctant to cyclize, giving trans-1-hydroxy compounds as the only isolated reaction products.
Angiotensin-converting enzyme inhibitors: N-substituted glycine derivatives
Suh,Regan,Skiles,et al.
, p. 563 - 570 (2007/10/02)
We report a series of novel dipeptides, which exhibit potent in vitro angiotensin-converting enzyme (ACE) inhibition. These dipeptides embody N-substituted glycine as the COOH terminus amino acid. The dipeptide L-lysyl-N-(2,3-dihydro-1Hinden-5-yl)glycine,
