848349-23-5Relevant academic research and scientific papers
Preparation method of 2-fluorophenyl azide compound
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Paragraph 0023; 0024, (2017/09/01)
The invention discloses a preparation method of a 2-fluorophenyl azide compound 4-(3-azido-propyl)-2-fluoro-1-methoxybenzene. According to the preparation method, 3-(3-fluoro-4-methoxyphenyl)acrylic acid is taken as a starting material, and a target product 5 is obtained by means of reducing, hydrogenating, loading Ms and carrying out an azido reaction. The product prepared by the method can be used as template micromolecules for synthesizing various compound libraries.
5,6,7,8-TETRAHYDRO-IMIDAZO[1,5-A]PYRAZINE DERIVATIVES
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Page/Page column 52, (2008/12/06)
The invention relates to 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives of formula (I),wherein X represents CH2 or O; R1 represents a phenyl group, which group is independently mono-, di-, or tri-substituted wherein the substituents are independently selected from the group consisting of (C1-4)alkyl, (C1-4)alkoxy, halogen, cyano, trifluoromethoxy and trifluoromethyl; R2 represents (C1-4)alkyl, (C1-4)alkoxy, (C2-4)alkenyl, halogen, cyano, hydroxymethyl, trifluoromethyl, C(O)NR5R6 or cyclopropyl; R3 represents (C1-4)alkyl, (C1-4)alkoxy-methyl or halogen; R4 represents (C1-4)alkyl; R5 represents hydrogen or (C1-4)alkyl; and R6 represents hydrogen or (C1-4)alkyl. The invention also relates to pharmaceutically acceptable salts of such compounds; and to the use of such compounds as medicaments; especially as orexin receptor antagonists.
