84837-76-3Relevant academic research and scientific papers
Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents
Apfel, Christian,Banner, David W.,Bur, Daniel,Dietz, Michel,Hirata, Takahiro,Hubschwerlen, Christian,Locher, Hans,Page, Malcolm G. P.,Pirson, Wolfgang,Rossé, Gérard,Specklin, Jean-Luc
, p. 2324 - 2331 (2007/10/03)
Low-molecular-weight β-sulfonyl- and β-sulfinylhydroxamic acid derivatives have been synthesized and found to be potent inhibitors of Escherichia coli peptide deformylase (PDF). Most of the compounds synthesized and tested displayed antibacterial activities that cover several pathogens found in respiratory tract infections, including Chlamydia pneumoniae, Mycoplasma pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. The potential of these compounds as antibacterial agents is discussed with respect to selectivity, intracellular concentrations in bacteria, and potential for resistance development.
SYNTHESIS WITH α-CYANOENAMINES. 2-DIETHYLAMINO-4-LITHIO-4-PHENYLTHIO-2-BUTENONITRILE AS A β-CARBOXYL VINYL ANION EQUIVALENT.
Lombaert,Stephane de,Lesur, Brigitte,Ghosez, Leon
, p. 4251 - 4254 (2007/10/02)
The lithio derivative of 2-diethylamino-4-phenylthio-2-butenonitrile is a practical equivalent of the unknown β-carboxyl-vinyl anion, as shown by its facile alkylation with alkyl halides, aldehydes and α-enones, followed by hydrolysis, oxidation and elimination.
