848416-07-9 Usage
Uses
Used in Pharmaceutical Industry:
Filgotinib is used as an anti-inflammatory and immunosuppressive agent for the treatment of autoimmune diseases such as rheumatoid arthritis, Crohn's disease, and ulcerative colitis. It modulates the immune response by inhibiting the JAK1 enzyme, reducing inflammation and alleviating symptoms associated with these conditions.
Additionally, filgotinib is being investigated for its potential use in other autoimmune diseases, such as psoriasis and lupus, due to its ability to regulate the immune system and reduce inflammation. Its selective inhibition of JAK1 may offer a targeted approach to treating these conditions, potentially leading to improved outcomes and reduced side effects compared to broader immunosuppressive therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 848416-07-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,8,4,1 and 6 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 848416-07:
(8*8)+(7*4)+(6*8)+(5*4)+(4*1)+(3*6)+(2*0)+(1*7)=189
189 % 10 = 9
So 848416-07-9 is a valid CAS Registry Number.
848416-07-9Relevant articles and documents
7-(4-SUBSTITUTED 3- CYCLOPROPYLAMINOMETHYL-1- PYRROLIDINYL) Q UINOLONECARBOXYLIC ACID DERIVATIVE
-
Page/Page column 28, (2008/06/13)
To provide novel quinolonecarboxylic acid compounds serving as safe, strong antibacterial agents that are effective against drug-resistant bacteria that are less susceptible to conventional antibacterial agents. SOLVING MEANS There are provided 7-(4-substituted-3-cyclopropylaminomethylpyrrolidinyl)quinolonecarboxylic acid derivatives (such as 1-cyclopropyl-7-[(3S,4S)-3-cyclopropylaminomethyl-4-fluoro-1-pyrrolidinyl]-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid) that exhibit strong antibacterial activity against gram-positive bacteria, such as MRSA, PRSP and VRE, while being safe. The compounds are shown by the following general formula (I):
