84846-34-4

Usage

Uses

Used in Pharmaceutical Industry:
2-Pyrrolidinecarboxamide, 4-hydroxy-N-phenyl-, (2S,4R)is used as a potential therapeutic agent for its antioxidant and anti-inflammatory properties. These properties may contribute to the development of new treatments for various diseases and conditions, such as inflammatory disorders and oxidative stress-related diseases.
Used in Drug Discovery:
2-Pyrrolidinecarboxamide, 4-hydroxy-N-phenyl-, (2S,4R)is used as a lead compound in drug discovery. Its unique structure and biological activities make it a promising candidate for further research and development, potentially leading to the identification of new drugs with improved efficacy and safety profiles.

Upstream product

• 84846-30-0 (2S,4R)-1-benzyloxycarbonyl-4-hydroxyprolinanilide 
• 62-53-3 aniline 
• 13504-85-3 (2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid 
• 13726-69-7 (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 
• 541-41-3 chloroformic acid ethyl ester 
• 130930-25-5 (R,R)-4-hydroxy-1-(benzyloxycarbonyl)pyrrolidine-2-carboxylic acid 

Downstream Products

• 84846-40-2 (2S,4R)-1-acetyl-4-hydroxyprolinanilidinyl acetate 

Relevant academic research and scientific papers

Enantioselective organocatalytic Biginelli reaction: Dependence of the catalyst on sterics, hydrogen bonding, and reinforced chirality

From a systematic investigation involving the synthesis of a series of catalysts and screening studies, the organocatalyst 16, which is sterically hindered, contains a strong hydrogen-bonding site, and is endowed with reinforced chirality, is shown to pro

The mimic of type II aldolases chemistry: Asymmetric synthesis of β-Hydroxy Ketones by Direct Aldol Reaction: Research Letter

An efficient direct aldol reaction has been developed for the synthesis of chiral β-hydroxy ketone using a combination of C1-symmetric chiral prolinamides based on o-phenylenediamine and zinc triflate as catalyst. The reaction was convenient to

An enantioselective Biginelli reaction catalyzed by a simple chiral secondary amine and achiral Bronsted acid by a dual-activation route

An enantioselective Biginelli reaction that proceeds by a dual-activation route has been developed by using a combined catalyst of a readily available trans-4-hydroxyproline-derived secondary amine and a Bronsted acid. Aromatic, heteroaromatic, and fusedr

The Enantioselective Michael Addition of Thiols to Cycloalkenones by Using (2S,4S)-2-Anilinomethyl-1-ethyl-4-hydroxypyrrolidine as Chiral Catalyst

Catalytic asymmetric addition of thiols to 2-cycloalkenone was studied by using the chiral amino alcohols, derived from L-hydroxyproline or (S)-proline, as base catalysts.Detailed investigation was carried out on the effects of the structure of the cataly