848482-94-0

Upstream product

• 537705-06-9 3-(2-methyl-4-aminophenoxy)-6-methylpyridine 
• 16499-60-8 4-chloro-5-fluoro-quinazoline 

Downstream Products

• 944160-46-7 N-{3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl}-5-[(2R)-pyrrolidin-2-ylmethoxy]quinazolin-4-amine 
• 871019-19-1 5-methoxy-N-{3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl}quinazolin-4-amine 
• 853002-44-5 5-{(1R)-2-[allyl(methyl)amino]-1-methylethoxy}-N-{3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl}quinazolin-4-amine 

Relevant academic research and scientific papers

QUINAZOLINE DERIVATIVES

A quinazoline derivative of the Formula (I): wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrosine kinase in a warm-blooded animal such as man.

QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS

A quinazoline derivative of the formula (I): (A chemical formula should be inserted here - please see paper copy enclosed) Formula I wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrosine kinase in a warm blooded animal such as man.

QUINAZOLINE DERIVATIVES AS ERBB RECEPTOR TYROSINE KINASES

The invention concerns quinazoline derivatives of the formula (I), wherein each of R1, R2, R3, R4, R5, R6, R7, X1, Q1, m and n have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of erbB receptor tyrosine kinases.