848484-65-1

Basic information

• Product Name: 3-ethyl-1-phenyl-2-phospholene 1-oxide
• Synonyms: 3-ethyl-1-phenyl-2-phospholene 1-oxide
• CAS NO: 848484-65-1
• Molecular Weight: 206.224
• Mol File: 848484-65-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-ethyl-1-phenyl-2-phospholene 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ethyl-1-phenyl-2-phospholene 1-oxide(848484-65-1)
• EPA Substance Registry System: 3-ethyl-1-phenyl-2-phospholene 1-oxide(848484-65-1)

Safety Data

• Hazardous Substances Data: 848484-65-1(Hazardous Substances Data)

Upstream product

• 707-61-9 3-Methyl-1-phenyl-2-phospholene 1-oxide 
• 74-88-4 methyl iodide 

Downstream Products

• 1254101-95-5 4-bromo-3-ethyl-1-phenyl-2-phospholene 1-oxide 

Relevant articles and documents

Preparation and characterization of novel 4-bromo-3,4-dimethyl-1-phenyl-2- phospholene 1-oxide and the analogous phosphorus heterocycles or phospha sugars

4-Bromo-3,4-dimethyl-1-phenyl-2-phospholene 1-oxide (3c) was first synthesized from 3,4-dimethyl-1-phenyl-2-phospholene 1-oxide (2c) by a bromo-radical substitution reaction occurred at C-4 position by N-bromosuccinimide and 2,2′-azobisisobutyronitrile. The novel phospha sugar analogue 3c exerted high anti-proliferative effect on U937 cells evaluated by MTT in vitro methods and was much more efficient than that of Gleevec, which is known as a molecule targeting chemotherapeutical agent. The substitution of 2-phospholenes at C-3 and C-4 position with methyl groups as well as 4-bromo substituent suggests a good anti-proliferative effect.