848485-49-4

Upstream product

• 1571-72-8 3-amino-4-hydroxybenzoic acid 
• 536-25-4 methyl 3-amino-4-hydroxybenzoate 
• 774213-81-9 methyl 3-[(trifluoroacetyl)amino]-4-{[(trifluoromethyl)sulfonyl]oxy}benzoate 
• 774213-80-8 methyl 4-hydroxy-3-[(trifluoroacetyl)amino]benzoate 
• 848485-44-9 methyl 2-(4-methoxyphenyl)-1H-indole-6-carboxylate 
• 1521-51-3 rac-3-bromocyclohexene 

Downstream Products

• 848485-50-7 methyl 3-cyclohexyl-2-(4-methoxyphenyl)-1H-indole-6-carboxylate 

Relevant academic research and scientific papers

INDOLES AND AZAINDOLES AS ANTIVIRAL AGENTS

The present invention relates to indoles and azaindoles of formula (I): wherein X1, X2, X3, X4, A1, Ar1, Ar, n, p and q are as defined herein and pharmaceutically acceptable salts thereof, useful in the prevention and treatment of hepatitis C virus infections.

Development and preliminary optimization of indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase

Allosteric inhibition of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase enzyme has recently emerged as a viable strategy toward blocking replication of viral RNA in cell-based systems. We report here a novel class of allosteric inhibitor of NS5B that shows potent affinity for the NS5B enzyme and effective inhibition of subgenomic HCV RNA replication in HUH-7 cells. Inhibitors from this class have promising characteristics for further development as anti-HCV agents.