848488-68-6

Upstream product

• 848488-65-3 4-(3-chloro-2-fluorophenylamino)-7-methoxyquinazoline-6-carbaldehyde 
• 848488-67-5 4-(3-chloro-2-fluoroanilino)-7-methoxy-6-quinazoline carboxylic acid methyl ester 

Downstream Products

• 862372-25-6 N-(3-chloro-2-fluorophenyl)-6-(chloromethyl)-7-methoxyquinazolin-4-amine hydrochloride 
• 848488-65-3 4-(3-chloro-2-fluorophenylamino)-7-methoxyquinazoline-6-carbaldehyde 

Relevant academic research and scientific papers

QUINAZOLINE DERIVATIVES

The invention concerns quinazoline derivatives of Formula (I) wherein each of R1, R3, R20, X1, X2, Z, W, (a) and (q) have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of turnours which are sensitive to inhibition of erbB receptor tyrosine kinases, particularly EGFR tyrosine kinase.

QUINAZOLINE DERIVATIVES

A quinazoline derivative of the formula (I) wherein: R1, R2, R3, R3a, R4, R5, R5a R6, R7, a, m and p are as defined in the description. Also claimed are pharmaceutical compositions containing the quinazoline derivative, the use of the quinazoline derivatives as medicaments and processes for the preparation of the quinazoline derivative. The quinazoline derivatives of formula (I), are useful in the treatment of hyperproliferative disorders such as a cancer.