84849-15-0Relevant articles and documents
Quantitative Structure-Inotropy Relationship Applied to Substituted Grayanotoxins
Shirai, Naohiro,Sakakibara, Jinsaku,Kaiya, Toyo,Kobayashi, Sawako,Hotta, Yoshihiro,Takeya, Kazumi
, p. 851 - 855 (2007/10/02)
Nine 14β-O-acylated grayanotoxins were synthesized by ozonolysis of 14,16-alkylidenegrayanotoxin III.The correlation between positive inotropic potency (PIE) in guinea pigs and physicochemical parameters (Vw, Mw, and Rm50) in 14,14-substituted