84855-54-9Relevant academic research and scientific papers
Palladium-Catalyzed Migratory Insertion of Carbenes and C-C Cleavage of Cycloalkanecarboxamides
Zhang, Peng,Zeng, Jia,Pan, Ping,Zhang, Xue-Jing,Yan, Ming
supporting information, p. 536 - 541 (2022/01/20)
A palladium catalyzed reaction of cycloalkanecarboxamides and diazomalonates or bis(phenylsulfonyl)diazomethane has been developed. The reaction proceeds via carbene migratory insertion and cascade C-C cleavage pathways. Cycloalkanecarboxamides with four to seven membered rings are applicable in the transformation. A series of ring opening products were prepared with moderate yields. The finding provides valuable clues for the development of new reactions involving carbene migratory insertion and the cleavage of unstrained C(sp3)-C(sp3) bonds.
A high-purity process for the preparation of nateglinide
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Paragraph 0028; 0029, (2017/05/04)
A preparation method of high-purity nateglinide comprises the following steps: trans-4-isopropyl-cyclohexanecarboxylic acid is taken as a starting material, acyl chloride obtained by chlorinating sulfoxide chloride reacts with D-phenylalanine, the reaction product is subjected to acid hydrolysis to obtain B-type nateglinide, and then the B-type nateglinide is transformed in ethyl alcohol to obtain H-type nateglinide. The method is simple to operate, the raw materials are easy to obtain, the yield is higher and the product quality is high.
A NOVEL AND IMPROVED PROCESS FRO THE PREPARATION OF NATEGLINIDE AND ITS POLYMORPH FORM-H
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Page/Page column 10, (2008/06/13)
Nateglinide is prepared by an improved process comprising reaction of trans-4-isopropyl cyclohexane carbonyl chloride with N,O-bis- trimethylsilyl protected D-phenyl alanine to give after aqueous workup, crude nateglinide which is converted to Nateglinide form- H using a mixture of cyclohexane / ethyl acetate. trans-4-isopropyl cyclohexane carbonyl chloride is prepared from trans-4- isopropyl cyclohexane carboxylic acid using oxalyl chloride.
