848555-18-0

Usage

Uses

Used in Pharmaceutical Industry:
4-Thiazolecarbonitrile, 2-(1-methylethyl)is utilized as a building block in the synthesis of various pharmaceuticals. Its unique structure and functional groups make it a valuable component in the development of novel drugs and bioactive compounds. 4-Thiazolecarbonitrile, 2-(1-methylethyl)-'s ability to form stable complexes with biological targets contributes to its potential use in creating new therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Thiazolecarbonitrile, 2-(1-methylethyl)serves as a key intermediate in the synthesis of various agrochemicals. Its incorporation into the molecular structure of these chemicals can enhance their effectiveness in pest control and crop protection, thereby contributing to increased agricultural productivity.
Used in Medicinal Chemistry Research:
4-Thiazolecarbonitrile, 2-(1-methylethyl)is employed as a research compound in the field of medicinal chemistry. Scientists use this versatile chemical to explore its interactions with biological systems and evaluate its potential as a precursor for the development of new pharmaceutical agents. Its unique properties make it an attractive candidate for studying structure-activity relationships and optimizing drug candidates.
Used in Chemical Process Development:
4-Thiazolecarbonitrile, 2-(1-methylethyl)may also be used in the research and development of new materials and chemical processes. Its reactivity and functional groups can be harnessed to create innovative chemical reactions and synthesize advanced materials with unique properties. 4-Thiazolecarbonitrile, 2-(1-methylethyl)-'s potential applications in material science and chemical engineering contribute to the advancement of various industries.

Upstream product

• 390386-23-9 2-isopropylthiazole-4-carboxylic acid amide 

Downstream Products

• 848555-21-5 5-[hydroxy-(2-nitrophenyl)methyl]-2-isopropylthiazole-4-carbonitrile 

Relevant academic research and scientific papers

SUBSTITUTED PIPERAZINES OF AZEPINES, OXAZEPINES, AND THIAZEPINES

Described herein are antipyschotic compounds of formula (I) wherein: is an optionally benzo-fused five or six member aromatic ring having zero to three hetero atoms independently selected from N, O, and S; R1 is hydrogen, (C1-6) fluoroalkyl, (C3-6) cycloalkyl, or (C1-4) alkyl, wherein the (C1-4) alkyl is unsubstituted or substituted with hydroxy, methoxy, ethoxy, OCH2CH2OH, -CN, imidazolidin-2-one, phenyl, or tetrazole wherein tetrazole is unsubstituted or substituted with (C1-4) alkyl; R2 is H, halogen, (C1-6) fluoroalkyl, (C3-6) cycloalkyl, OR6, SR6, NO2, CN, COR6, C(O)OR6, C(OH)R6, CONR7R8, phenyl or (C1-6) alkyl, wherein the (C1-6) alkyl is unsubstituted or substituted with a hydroxy; R3 is hydrogen, (C 1-6)fluoroalkyl , (C3-6) cycloalkyl, (C2-6) alkenyl, phenyl, monocyclic heteroaromatic, bicyclic heteroaromatic, or (C1-4)alkyl wherein (C1-4) alkyl is unsubstituted or substituted with a phenyl; R4 and R5 are independently selected from hydrogen, halogen, (C1-6) alkyl, (C1-6) fluoroalkyl, OR9, SR9, NO2, CN, or COR9; R6 is hydrogen, (C1-6) fluoroalkyl, or (C1-6) alkyl; R7 and R8 are independently hydrogen, or (C1-6) alkyl; R9 is hydrogen, (C1-6) fluoroalkyl, (C1-6) alkyl; Alk is (C1-4) alkylene unsubstituted or substituted with a hydroxy; Y is oxygen, sulfur, SO2, or a bond; X is CH2, C=O, S, O, or SO2; Z is hydrogen, halogen, (C1-6) alkyl, (C1-6)fluoroalkyl, -OH, (C1-6) alkoxy, (C1-6) fluoroalkoxy, (C1-6) alkylthio, (C1-6) acyl, (C1-4)alkylsulfonyl, -OCF3, -NO2, - CN, carboxamido which may be substituted on the nitrogen by one or two (C1-4) alkyl groups, and -NH2 in which one of the hydrogens may be replaced by a (C1-4) alkyl group and the other hydrogen may be replaced by either a (C1-4) alkyl group, a (C1-6) acyl group, or a (C1-4) alkylsulfonyl group; the phenyl of R1, R2 or R3 is independently unsubstituted or substituted with one to three substituents independently selected from Z; the monocyclic heteroaromatic of R3 is unsubstituted or substituted with one to three substituents independently selected from Z; the bicyclic heteroaromatic of R3 is unsubstituted or substituted with one to three substituents independently selected from Z; and salts, solvates, and crystal forms thereof. Also described are the use of the compounds of formula (I) as antagonists of the dopamine D2 receptor and as agents for the treatment of psychosis and bipolar disorders, and pharmaceutical formulations of the compounds of formula (I).