848568-08-1

Upstream product

• 848568-07-0 4-pentenyl 3-O-(2,3,4-tri-O-acetyl-α-L-fucopyranosyl)-2-acetamido-2-deoxy-β-D-glucopyranoside 
• 613-90-1 benzoyl cyanide 
• 128902-91-0 1-O-(4-penten-1-yl)-2-acetamido-2-deoxy-β-D-glucopyranoside 
• 128902-88-5 pent-4-enyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranoside 
• 32727-30-3 1,2,3,4-tetra-O-trimethylsilyl-α-L-fucopyranose 
• 821-09-0 n-Pent-4-enyl alcohol 
• 3006-60-8 2-acetamido-3,4,6-tri-O-acetyl-D-glucopyranosyl acetate 

Relevant academic research and scientific papers

Synthesis of a Ley neoglycoconjugate and Ley- functionalized gold glyconanoparticles

The thiol functionalized Ley neoglycoconjugate 1 has been synthesized and used to prepare the Ley-functionalized gold glyconanoparticle 2. The synthesis of 1 has been carried out using a stepwise glycosylation strategy in which a suitably protected d-glucosamine derivative has been sequentially glycosylated at position 3 and then at position 4 with conveniently protected α-l-fucopyranosyl and β-d-galactopyranosyl donors, respectively. The galactosylation step afforded the imidate 16 when the glycosyl acceptor contained a N-acetyglucosamine unit and the desired 4-O-galactopyranosyl derivative when the amino function was protected as phthalimido group. The gold glyconanoparticle 2 has been prepared from 1 and has been characterized by NMR spectroscopy and transmission electron microscopy (TEM).