848568-09-2Relevant academic research and scientific papers
Synthesis of a Ley neoglycoconjugate and Ley- functionalized gold glyconanoparticles
De Paz, Jose-Luis,Ojeda, Rafael,Barrientos, Africa G.,Penades, Soledad,Martin-Lomas, Manuel
, p. 149 - 158 (2005)
The thiol functionalized Ley neoglycoconjugate 1 has been synthesized and used to prepare the Ley-functionalized gold glyconanoparticle 2. The synthesis of 1 has been carried out using a stepwise glycosylation strategy in which a suitably protected d-glucosamine derivative has been sequentially glycosylated at position 3 and then at position 4 with conveniently protected α-l-fucopyranosyl and β-d-galactopyranosyl donors, respectively. The galactosylation step afforded the imidate 16 when the glycosyl acceptor contained a N-acetyglucosamine unit and the desired 4-O-galactopyranosyl derivative when the amino function was protected as phthalimido group. The gold glyconanoparticle 2 has been prepared from 1 and has been characterized by NMR spectroscopy and transmission electron microscopy (TEM).
