848591-08-2Relevant academic research and scientific papers
2-ALKOXY-6-AMINO-5-HALOGENO-N-(1-SUBSTITUTED-4-PIPERIDINYL)PYRIDINE-3-CARBOXAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
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PROBLEM TO BE SOLVED: To provide a compound exhibiting high affinity for serotonin 4 receptor and useful as a digestive tract motion promoting agent or digestive tract function ameliorating agent. SOLUTION: The compound is represented by the formula(I), or an acid addition salt thereof and an intermediate thereof are provided. In formula(I), R1 is a halogen atom; R2 is H or a lower alkyl; R3 is H, a lower alkyl or the like; R4 is a lower alkyl; A is a group represented by the formula: Z-N(Q1)(Q2) or CO-R5, wherein Z is CO, CS or the like; Q1 and Q2 are each H, a lower alkyl or the like, or joined together with the nitrogen atom to which Q1 and Q2 are bound to form a pyrrolidine ring, piperidine ring or the like; and R5 is H, a lower alkyl, lower alkoxy, lower alkoxycarbonyl or the like.
