848608-06-0Relevant articles and documents
6′-Methylpyrido[3,4-b]norhomotropane: Synthesis and outstanding potency in relation to the α4β2 nicotinic receptor pharmacophore model
Kanne, David B.,Tomizawa, Motohiro,Durkin, Kathleen A.,Casida, John E.
, p. 877 - 881 (2007/10/03)
6′-Methylpyrido[3,4-b]norhomotropane [synthesis as the racemate reported here] is more potent at the α4β2 nicotinic receptor than any previous bridged nicotinoid. The two nitrogens and 6′-methyl substituent are superimposable on the two nitrogens and 6-chloro substituent of epibatidine, with the best fit on comparing the chair conformer of the (1R)- pyridonorhomotropane with natural (1R)-epibatidine. In this pharmacophore model, the 6′-methyl substituent may be equivalent to the acetyl methyl of acetylcholine.
