848611-05-2Relevant academic research and scientific papers
Reactions of cyanothioacetamide: Synthesis of several new thioxohydro-pyridine-3-carbonitrile and thieno[2,3-b]pyridine derivatives
Attaby, Fawzy A.,Eldin, Sanaa M.,Elneairy, Mohamed A. A.,El-Louh, Ali K. K.
, p. 2205 - 2220 (2004)
Cyanothioacetamide (1) reacted with α,β-unsaturated carbonyl compounds 2a-d to afford thioxohydropyridine-3-carbonitriles 5a-d, which were used as the starting materials for the preparation of several thienopyridines via their reactions with active halogen-containing compounds, e.g., 2-bromo-1-phenylethanone (7a), 2-bromo-1-p-tolylethanone (7b), chloroacetone (10a), α-chloroacetylacetone (10b), and chloroacetic acid ethyl ester (13). The structure of the newly synthesized heterocyclic compounds were established based on the data of elemental analyses, IR, 1H NMR, and mass spectra.
