848645-01-2Relevant academic research and scientific papers
Stereoselective synthesis of (2S,4R)-4-hydroxypipecolic acid
Occhiato, Ernesto G.,Scarpi, Dina,Guarna, Antonio
, p. 524 - 531 (2008/09/18)
A new synthetic route to enantiopure (2S,4R)-4-hydroxypipecolic acid from commercial ethyl (3S)-4-chloro-3-hydroxybutanoate is reported. The synthesis is based on the Pd-catalyzed methoxycarbonylation of a 4-alkoxy-substituted δ-valerolactam-derived vinyl triflate followed by the stereocontrolled hydrogenation of the enamine double bond. The final product was obtained after exhaustive hydrolysis in 20 % yield over 10 steps. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
Novel process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate
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Page/Page column 2, (2008/06/13)
In one aspect, the present invention provides a novel process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate, a key intermediate for the preparation of HMG-CoA reductase inhibitor.
