848648-52-2Relevant academic research and scientific papers
Novel procedure for the coupling of sterically hindered electron-deficient anilines to the 6-position of the purine core
Leenders, Ruben,Heeres, Jan,Vandenput, Dirk,Guillemont, Jerome,Lewi, Paul
, p. 3246 - 3250 (2011/10/01)
Sterically hindered electron-deficient anilines are coupled to the 6-position of the purine core only when activated as their corresponding TFA-amide. The free anilines did not react under all conditions tested. After aqueous work-up, the TFA-group is los
