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Usage

Uses

Used in Organic Synthesis:
2,3,4,5,6-PENTAFLUOROPHENYL 4-BROMOBENZENESULFONATE is used as a reagent in organic synthesis for its high reactivity, facilitating the formation of new chemical bonds and structures.
Used in Chemical Research:
In the field of chemical research, 2,3,4,5,6-PENTAFLUOROPHENYL 4-BROMOBENZENESULFONATE serves as an intermediate, contributing to the development of new methodologies and understanding of chemical reactions.
Used in Pharmaceutical Industry:
2,3,4,5,6-PENTAFLUOROPHENYL 4-BROMOBENZENESULFONATE is used as a building block in the production of pharmaceuticals, aiding in the creation of new drugs and improving the efficacy of existing ones.
Used in Agrochemical Industry:
2,3,4,5,6-PENTAFLUOROPHENYL 4-BROMOBENZENESULFONATE is also utilized in the agrochemical sector, where it is employed in the synthesis of pesticides and other agricultural chemicals to enhance crop protection and yield.
Used in Material Development:
2,3,4,5,6-PENTAFLUOROPHENYL 4-BROMOBENZENESULFONATE is used in the development of new materials, contributing to the advancement of various material sciences and the creation of innovative products with unique properties.
Used in Synthesis of Complex Organic Compounds:
As a key component in the synthesis of more complex organic compounds, 2,3,4,5,6-PENTAFLUOROPHENYL 4-BROMOBENZENESULFONATE is instrumental in expanding the scope of organic chemistry and enabling the discovery of novel molecules with potential applications in various fields.

Upstream product

• 771-61-9 2,3,4,5,6-pentafluorophenol 
• 673-40-5 4-bromobenzenediazonium tetrafluoroborate 
• 5467-74-3 4-Bromophenylboronic acid 
• 98-58-8 4-bromobenzenesulfonyl chloride 

Downstream Products

• 928656-94-4 pentafluorophenyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonate 
• 498-83-9 4-bromobenzenesulfonyl fluoride 
• 886021-96-1 (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 4-bromobenzenesulfonate ester 
• 1375455-82-5 5-methyl-N-(1-methyl-1H-pyrazol-4-yl)-4-(4-(morpholinosulfonyl)phenyl)pyrimidin-2-amine 
• 1375457-32-1 perfluorophenyl 4-(5-methyl-2-(1-methyl-1H-pyrazol-4-ylamino)pyrimidin-4-yl)benzenesulfonate 

Relevant academic research and scientific papers

Pentafluorophenyl sulfonate ester as a protecting group for the preparation of biaryl- and heterobiaryl sulfonate esters

(Chemical Equation Presented) The use of the pentafluorophenyl (PFP) group as a sulfonic acid protecting group has allowed the synthesis of new biaryl- and heterobiaryl-PFP-sulfonate esters by use of the Suzuki-Miyaura reaction. The successful employment

One-Pot Synthesis of Pentafluorophenyl Sulfonic Esters via Copper-Catalyzed Reaction of Aryl Diazonium Salts, DABSO, and Pentafluorophenol

Pentafluorophenyl (PFP) sulfonic esters were synthesized via a copper-catalyzed one-pot multicomponent reaction of aryl diazonium tetrafluoroborate, DABSO (DABCO·(SO2)2), and pentafluorophenol. The reaction system provided the desired pentafluorophenyl sulfonic esters in good yields and exhibited excellent functional group tolerance. In addition, the generated PFP sulfonic esters were successfully applied in Sonogashira, Suzuki, Chan-Evans-Lam, and decarboxylative coupling reactions.

Copper-Catalyzed Synthesis of Activated Sulfonate Esters from Boronic Acids, DABSO, and Pentafluorophenol

The synthesis of pentafluorophenyl (PFP) sulfonate esters based on the Pd-catalyzed sulfination of aryl and heteroaryl boronic acids is reported. The sulfinate intermediates are converted in situ to the corresponding sulfonate esters using a copper-catalyzed oxidative process, providing a broad range of PFP esters in good yields.

PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS

The present invention relates to compounds of formula (I), wherein R1 to R3, X1, X2 have the meaning as cited in the description and the claims. Said compounds are useful as TYK2 inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds as well as their use as medicaments.

O-HYDROXY- AND O-AMINO BENZAMIDE DERIVATIVES AS IKK2 INHIBITORS

A compound of Formula (I).