848649-47-8

Upstream product

• 149359-06-8 1-[5-(4,4'-dimethoxytrityl)-3-(t-butyldimethylsilyl)-4-thio-beta-D-ribofuranosyl]uracil 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 159981-11-0 N⁴-benzoyl-1-[2-O-(tert-butyldimethylsilyl)-5-O-(4,4'-dimethoxytrityl)-4-thio-β-D-ribofuranosyl]cytosine 
• 159981-09-6 N⁴-benzoyl-1-[5-O-(4,4'-dimethoxytrityl)-4-thio-β-D-ribofuranosyl]cytosine 
• 172531-76-9 N⁴-benzoyl-1-[2-O-(tert-butyldimethylsilyl)-3-O-[(2-cyanoethyl)(N,N-diisopropylamino)phosphino]-5-O-(4,4'-dimethoxytrityl)-4-thio-β-D-ribofuranosyl]cytosine 
• 159981-13-2 N-benzoyI-1-[S-(4,4'-dimethoxytrityl)-3-(t-butyIdimethylsilyl)-4-thio-β-D-ribofuranosyl]cytosine 

Relevant academic research and scientific papers

Improving RNA interference in mammalian cells by 4′-thio-modified small interfering RNA (siRNA): Effect on siRNA activity and nuclease stability when used in combination with 2′-O-alkyl modifications

A systematic structure-activity relationship study of 4′-thioribose containing small interfering RNAs (siRNAs) has led to the identification of highly potent and stable antisense constructs. To enable this optimization effort for both in vitro and in vivo