848653-55-4Relevant academic research and scientific papers
Chemo-, regio- and stereoselective heck arylation of allylated malonates: Mechanistic insights by ESI-MS and synthetic application toward 5-arylmethyl-γ-lactones
Oliveira, Caio C.,Marques, Marcelo V.,Godoi, Marla N.,Regiani, Thas,Santos, Vanessa G.,Santos, Emerson A.F. Dos,Eberlin, Marcos N.,S, Marcus M.,Correia, Carlos R.D.
, p. 5180 - 5183 (2014/12/11)
We describe herein a general method for the controlled Heck arylation of allylated malonates. Both electron-rich and electron-poor aryldiazonium salts were readily employed as the aryl-transfer agents in good yields and in high chemo-, regio-, and stereoselectivity without formation of decarboxylated byproducts. Reaction monitoring via ESI-MS was used to support the formation of chelated Pd species through the catalytic cycle. Additionally, some Heck adducts were successfully used in the total synthesis of pharmacologically active γ-lactones.
Synthesis and biological activity of the tea catechin metabolites, M4 and M6 and their methoxy-derivatives
Lambert, Joshua D.,Rice, Joseph E.,Hong, Jungil,Hou, Zhe,Yang, Chung S.
, p. 873 - 876 (2007/10/03)
Syntheses are reported for metabolites M4 (1) and M6 (2) of the green tea polyphenols epicatechin (EC) and epigallocatechin (EGC) and their gallate derivatives. Several methoxy-derivatives of 1 and 2 were also prepared. Compounds 1 and 2 were evaluated for growth inhibitory activity against a panel of immortalized and malignant human cell lines with 1 being the more active compound. The possible antiinflammatory activity of 1 and its trimethoxy derivative was also evaluated. Neither compound inhibited the release of arachidonic acid, although 1 inhibited NO production by 50% at 20 μM.
