848668-88-2Relevant academic research and scientific papers
New triple-helix DNA stabilizing agents
Strekowski, Lucjan,Hojjat, Maryam,Wolinska, Ewa,Parker, Alesia N.,Paliakov, Ekaterina,Gorecki, Tadeusz,Tanious, Farial A.,Wilson, W.David
, p. 1097 - 1100 (2005)
Several substituted quinolin-4-amines and heteroaromatic analogs were synthesized and evaluated for interaction with triplex polydA·2polydT and duplex polydA·polydT by using UV-thermal melting experiments. Excellent triple-helix DNA ligands with high affinity toward T·A·T triplets and triple/duplex selectivity were designed through a rational approach.
