848696-72-0

Usage

Structure

Benzene derivative with a bromomethyl group, a chloro group, and two methoxy groups

Applications

a. Organic synthesis
b. Precursor for pharmaceuticals and agrochemicals
c. Production of dyes and fine chemicals

Industrial applications

Versatile chemical reactivity allows for various uses

Safety precautions

Toxic and can cause skin and eye irritation; handle with care

Importance

Has significant industrial and synthetic applications, but requires proper safety measures

Upstream product

• 5417-17-4 2-chloro-3,4-dimethoxybenzaldehyde 
• 93983-13-2 2-chloro-3,4-dimethoxybenzyl alcohol 

Downstream Products

• 1400793-01-2 C₂₄H₃₆ClN₃O₇ 
• 1422528-62-8 1-(azidomethyl)-2-chloro-3,4-dimethoxybenzene 

Relevant academic research and scientific papers

Synthesis of 2,4-unsubstituted quinoline-3-carboxylic acid ethyl esters from arylmethyl azides via a domino process

A convenient synthesis of 2,4-unsubstituted quinoline-3-carboxylic acid ethyl esters via a domino process is described. The synthesis employs arylmethyl azides as the precursor which undergoes an acid-promoted rearrangement to give an N-aryl iminium ion. Following the addition with ethyl 3-ethoxyacrylate, intramolecular electrophilic aromatic substitution, elimination and subsequent oxidation, the quinoline products were obtained in moderate to excellent yields.

Synthesis and in vitro antibacterial activity of gemifloxacin derivatives containing a substituted benzyloxime moiety

A series of novel gemifloxacin (GMFX) derivatives containing a substituted benzyloxime moiety with remarkable improvement in lipophilicity were synthesized. The target compounds evaluated for their in vitro antibacterial activity against representative strains. Our results reveal that most of the target compounds have considerable potency against all of the tested Gram-positive strains including MRSA and MRSE (MIC: 90: 1 μg/mL) is 8-fold more active than GMFX, and 2-fold more active than GMFX and moxifloxacin against MRSE clinical isolates (MIC90: 4 μg/mL). Crown Copyright

Synthesis and biological activity of pyridopyridazin-6-one p38α MAP kinase inhibitors. Part 2

This manuscript concludes the Structure Activity Relationship (SAR) on the pyridazinone scaffold and identifies a compound with subnanomolar p38α activity and 24 h coverage in the rat arthritis efficacy model.

PYRROLIDINEANILINES

The present invention relates to a compotind represented by the following formula I or a pharmaceutically acceptable salt thereof; wherein R1, R2, and y are defined herein. The present invention further relates to compositions that include the compound of the present invention as well as a method of treating a patient from endometreosis or uterine fibroids.

NOVEL HETEROCYCLIC COMPOUNDS AS HSP90-INHIBITORS

Novel heterocyclic compounds are described and demonstrated to have utility as Heat Shock Protein 90 (HSP90) inhibiting agent. Method of synthesis and use of such compounds are also described.