848731-67-9

Basic information

• Product Name: Benzene, 1-(2-methylpropyl)-4-[(1E)-2-nitroethenyl]-
• CAS NO: 848731-67-9
• Molecular Formula: C12H15NO2
• Molecular Weight: 205.257
• Mol File: 848731-67-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(2-methylpropyl)-4-[(1E)-2-nitroethenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(2-methylpropyl)-4-[(1E)-2-nitroethenyl]-(848731-67-9)
• EPA Substance Registry System: Benzene, 1-(2-methylpropyl)-4-[(1E)-2-nitroethenyl]-(848731-67-9)

Safety Data

• Hazardous Substances Data: 848731-67-9(Hazardous Substances Data)

Upstream product

• 75-52-5 nitromethane 
• 40150-98-9 4-(2-methyl-1-propyl)benzaldehyde 

Downstream Products

• 51146-56-6 (S)-ibuprofen 

Relevant articles and documents

Cu-catalysed asymmetric 1,4-addition of Me3Al to nitroalkenes. Synthesis of (+)-ibuprofen

Trimethylaluminium undergoes enantioselective (ee up to 93%) copper-catalysed Michael addition to various nitroalkenes. Copper thiophenecarboxylate (CuTC) (2 mol %) and 4 mol % of a chiral phosphoramidite ligand are sufficient for a complete and clean reaction. The synthesis of (+)-ibuprofen is described with 82% ee.