848761-00-2

Basic information

• Product Name: 4-Oxazolecarboxylic acid, 2-[(1S)-1-amino-2-(phenylmethoxy)ethyl]-, methyl ester, monohydrochloride
• CAS NO: 848761-00-2
• Molecular Formula: C14H16N2O4.ClH
• Molecular Weight: 312.753
• Mol File: 848761-00-2.mol

Chemical Properties

• CAS DataBase Reference: 4-Oxazolecarboxylic acid, 2-[(1S)-1-amino-2-(phenylmethoxy)ethyl]-, methyl ester, monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Oxazolecarboxylic acid, 2-[(1S)-1-amino-2-(phenylmethoxy)ethyl]-, methyl ester, monohydrochloride(848761-00-2)
• EPA Substance Registry System: 4-Oxazolecarboxylic acid, 2-[(1S)-1-amino-2-(phenylmethoxy)ethyl]-, methyl ester, monohydrochloride(848761-00-2)

Safety Data

• Hazardous Substances Data: 848761-00-2(Hazardous Substances Data)

Upstream product

• 817625-25-5 (S)-2-((S)-3-benzyloxy-2-tert-butoxycarbonylaminopropionylamino)-3-hydroxypropionic acid methyl ester 
• 23680-31-1 BOC-O-benzyl-L-serine 
• 1095973-66-2 2-[(1S)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-(phenylmethoxy)ethyl]-2-(4S)-oxazoline methyl ester 

Downstream Products

• 1355992-83-4 C₅₈H₆₀N₈O₁₅ 
• 1355992-84-5 C₅₂H₄₈N₈O₁₂ 
• 1355992-85-6 C₅₂H₄₈N₈O₁₂ 
• 301662-30-6 2-((S)-2-Benzyloxy-1-{[2-((S)-2-benzyloxy-1-tert-butoxycarbonylamino-ethyl)-oxazole-4-carbonyl]-amino}-ethyl)-oxazole-4-carboxylic acid methyl ester 
• 860791-85-1 2-{(S)-1-[(2-{[(R)-1-((2S,3S)-2-tert-butoxycarbonylamino-3-methylpentanoylamino)-2-methylpropylamino]methyl}[2,4';2',4]teroxazole-4-carbothioyl)amino]-2-hydroxyethyl}-5-phenyloxazole-4-carboxylic acid methyl ester 
• 848761-08-0 2-{(S)-1-[(2''-{[(S)-1-((2S,3S)-2-tert-butoxycarbonylamino-3-methylpentanoylamino)-2-methylpropylamino]methyl}[2,4';2',4'']teroxazole-4-carbothioyl)amino]-2-hydroxyethyl}-5-phenyloxazole-4-carboxylic acid methyl ester 
• 848761-10-4 C₃₄H₃₆N₈O₈S 
• 848761-14-8 C₃₄H₃₆N₈O₈S 
• 848761-11-5 C₃₄H₃₄N₈O₇S 
• 848761-15-9 C₃₄H₃₄N₈O₇S 
• 848761-05-7 2-[(S)-1-{[2''-(tert-butoxycarbonylaminomethyl)[2,4':2';4'']teroxazole-4-carbonyl]amino}-2-(tert-butyldimethylsilanyloxy)ethyl]-5-phenyloxazole-4-carboxylic acid methyl ester 
• 848761-06-8 2-[(S)-1-{[2''-(tert-butoxycarbonylaminomethyl)[2,4':2';4'']teroxazole-4-carbothioyl]amino}-2-(tert-butyldimethylsilanyloxy)ethyl]-5-phenyloxazole-4-carboxylic acid methyl ester 
• 848761-02-4 2-((S)-2-benzyloxy-1-{[2-(tert-butoxycarbonylaminomethyl)oxazole-4-carbonyl]amino}ethyl)oxazole-4-carboxylic acid methyl ester 

Relevant articles and documents

A convenient method for synthesis of tetraoxazole peptide macrocycles

G-quadruplex DNA plays important regulatory roles in the maintenance of telomere length and transcriptions inhibition of such oncogenes as c-myc, and thus has become an attractive target for the development of anti-cancer therapeutic agents. Poly-oxazole macrocycles are a promising new class of G-quadruplex binding ligands. Herein is described the synthesis of a tetraoxazole peptide macrocycle and an epimerization product. The synthetic unit was prepared by cyclization-oxidation of a diserine with one hydroxyl protected. Two-cycle coupling of the unit gave a linear tetraoxazole amide. The targeted molecule and the epimerization product were obtained after macrocyclization of the linear precursor and following removal of the protecting benzyl groups. With structural similarities to the most potent G-quadruplex stabilizer telomestatin, these two molecules might potentially be used to probe the biological significance of G-quadruplex' in vivo.