848772-89-4

Upstream product

• 99-24-1 methyl galloate 
• 149-91-7 3,4,5-trihydroxybenzoic acid 
• 116119-01-8 methyl 7-hydroxybenzo[d][1,3]dioxole-5-carboxylate 
• 142531-43-9 methyl 7-(benzyloxy)benzo[d][1,3]dioxole-5-carboxylate 
• 526221-05-6 2-ethoxy-7-hydroxy-benzo[1,3]dioxole-5-carboxylic acid methyl ester 
• 79831-86-0 methyl 3-(benzyloxy)-4,5-dihydroxybenzoate 

Downstream Products

• 81474-47-7 methyl-6-bromo-7-methoxybenzo [d] [1, 3] dioxole-5-carboxylate 

Relevant academic research and scientific papers

Nitrogen-containing biaromatic ring compounds as well as preparation method and application thereof

The invention relates to nitrogen-containing biaromatic ring compounds, a preparation method and an application, namely a pharmaceutical composition consisting of the compound as an effective component, a preparation method and an application of the compound in resisting liver cancer. A series of nitrogen-containing biaromatic ring compounds with novel structures are synthesized, generation of miRNA is induced by regulating TRBP, a good anti-liver cancer effect is shown, small molecules have a relatively strong inhibiting effect on proliferation of liver cancer cells, individual compounds even have a better curative effect than enoxacin, no similar structure has the effect before, and the compounds have good development prospects.

Towards the Total Synthesis of Schisandrene: Stereoselective Synthesis of the Dibenzocyclooctadiene Lignan Core

A stereoselective synthesis of the dibenzocyclooctadiene lignan core of the natural product schisandrene is described. Starting from readily available gallic acid, the synthetic strategy involves Suzuki-Miyaura cross-coupling, Stille reaction, and ring-closing metathesis (RCM) in the reaction sequence. The required asymmetric center at C-7′ was established by an asymmetric reduction of a keto compound using the Corey-Bakshi-Shibata (CBS) catalyst. In our approach, the eight-membered ring was achieved by RCM for the first time.

Nitrogen-Containing Biphenyl Compounds, Pharmaceutical Compositions of Same, Preparation Methods and Anti-HIV-1 Uses Thereof

Nitrogen-containing biphenyl compounds as represented by formula (I), pharmaceutically acceptable salts or derivatives thereof, pharmaceutical compositions, and preparation methods therefore, and anti-HIV-1 use of the compound. Each substituent group in formula (I) is as defined in the description.

An improved method for the synthesis of γ-DDB

A mild and efficient method for the synthesis γ-DDB has been developed through anhydride-linker assisted intramolecular Ullmann reaction. Highly regioselective bromination of differentially protected gallate was realized by virtue of the introduction of NBS.

Synthesis of unsymmetrical biphenyls as potent cytotoxic agents

Twenty-six unsymmetrical biphenyls were synthesized and evaluated for cytotoxic activity against DU145, A549, KB and KB-Vin tumor cell lines. Three compounds 27, 35 and 40 showed very potent activity against the HTCL panel with an IC50 value range of 0.04-3.23 μM. In addition, fourteen active compounds were all more potent against the drug-resistant KB-Vin cell line than the parental KB cell line. Preliminary SAR analysis indicated that two bulky substituents on the 2,2′-positions of unsymmetrical biphenyl skeleton are necessary and crucial for in vitro anticancer activity, thus providing a good starting point to develop unsymmetrical biphenyls as novel anticancer agents.

Multi-functionalization of gallic acid towards improved synthesis of α- and β-DDB

The synthesis of mono-, di- and trisubstituted gallic acids and their ester with similar or different groups including different acetal and ketals is described. Regioselective bromination on two ortho-positions of methyl gallate, which is very crucial for many organic syntheses, was achieved in high yield and purity. The α- and β-DDB were synthesized in high overall yield and purity from the regioselective bromoderivatives.