848772-89-4

Basic information

• Product Name: Methyl 6-broMo-7-hydroxybenzo[d][1,3]dioxole-5-carboxylate
• Synonyms: Methyl 6-broMo-7-hydroxybenzo[d][1,3]dioxole-5-carboxylate
• CAS NO: 848772-89-4
• Molecular Formula: C9H7BrO5
• Molecular Weight: 275.05288
• Mol File: 848772-89-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 110-111 °C
• Boiling Point: 356.3±42.0 °C(Predicted)
• Appearance: /
• Density: 1.796±0.06 g/cm3(Predicted)
• PKA: 7.24±0.20(Predicted)
• CAS DataBase Reference: Methyl 6-broMo-7-hydroxybenzo[d][1,3]dioxole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 6-broMo-7-hydroxybenzo[d][1,3]dioxole-5-carboxylate(848772-89-4)
• EPA Substance Registry System: Methyl 6-broMo-7-hydroxybenzo[d][1,3]dioxole-5-carboxylate(848772-89-4)

Safety Data

• Hazardous Substances Data: 848772-89-4(Hazardous Substances Data)

Upstream product

• 116119-01-8 methyl 7-hydroxybenzo[d][1,3]dioxole-5-carboxylate 
• 149-91-7 3,4,5-trihydroxybenzoic acid 
• 99-24-1 methyl galloate 
• 79831-86-0 methyl 3-(benzyloxy)-4,5-dihydroxybenzoate 
• 142531-43-9 methyl 7-(benzyloxy)benzo[d][1,3]dioxole-5-carboxylate 
• 526221-05-6 2-ethoxy-7-hydroxy-benzo[1,3]dioxole-5-carboxylic acid methyl ester 

Downstream Products

• 81474-47-7 methyl-6-bromo-7-methoxybenzo [d] [1, 3] dioxole-5-carboxylate 

Relevant articles and documents

Nitrogen-containing biaromatic ring compounds as well as preparation method and application thereof

The invention relates to nitrogen-containing biaromatic ring compounds, a preparation method and an application, namely a pharmaceutical composition consisting of the compound as an effective component, a preparation method and an application of the compound in resisting liver cancer. A series of nitrogen-containing biaromatic ring compounds with novel structures are synthesized, generation of miRNA is induced by regulating TRBP, a good anti-liver cancer effect is shown, small molecules have a relatively strong inhibiting effect on proliferation of liver cancer cells, individual compounds even have a better curative effect than enoxacin, no similar structure has the effect before, and the compounds have good development prospects.

Nitrogen-Containing Biphenyl Compounds, Pharmaceutical Compositions of Same, Preparation Methods and Anti-HIV-1 Uses Thereof

Nitrogen-containing biphenyl compounds as represented by formula (I), pharmaceutically acceptable salts or derivatives thereof, pharmaceutical compositions, and preparation methods therefore, and anti-HIV-1 use of the compound. Each substituent group in formula (I) is as defined in the description.

Synthesis of unsymmetrical biphenyls as potent cytotoxic agents

Twenty-six unsymmetrical biphenyls were synthesized and evaluated for cytotoxic activity against DU145, A549, KB and KB-Vin tumor cell lines. Three compounds 27, 35 and 40 showed very potent activity against the HTCL panel with an IC50 value range of 0.04-3.23 μM. In addition, fourteen active compounds were all more potent against the drug-resistant KB-Vin cell line than the parental KB cell line. Preliminary SAR analysis indicated that two bulky substituents on the 2,2′-positions of unsymmetrical biphenyl skeleton are necessary and crucial for in vitro anticancer activity, thus providing a good starting point to develop unsymmetrical biphenyls as novel anticancer agents.