848773-36-4

Basic information

• Product Name: Phosphinic acid, [(2S)-3-chloro-2-[(trimethylsilyl)oxy]propyl](cyclohexylmethyl)-, ethyl ester
• CAS NO: 848773-36-4
• Molecular Formula: C15H32ClO3PSi
• Molecular Weight: 354.93
• Mol File: 848773-36-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Phosphinic acid, [(2S)-3-chloro-2-[(trimethylsilyl)oxy]propyl](cyclohexylmethyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphinic acid, [(2S)-3-chloro-2-[(trimethylsilyl)oxy]propyl](cyclohexylmethyl)-, ethyl ester(848773-36-4)
• EPA Substance Registry System: Phosphinic acid, [(2S)-3-chloro-2-[(trimethylsilyl)oxy]propyl](cyclohexylmethyl)-, ethyl ester(848773-36-4)

Safety Data

• Hazardous Substances Data: 848773-36-4(Hazardous Substances Data)

Upstream product

• 67843-74-7 (S)-epichlorohydrin 
• 848773-35-3 C₁₂H₂₇O₂PSi 

Downstream Products

• 848773-37-5 ethyl (3-amino-2(R)-hydroxypropyl)(cyclohexylmethyl)phosphinate 
• 169105-45-7 ethyl (3-chloro-2(S)-hydroxypropyl)(cyclohexylmethyl)phosphinate 

Relevant articles and documents

Process for the preparation of 3-amino-2-hydroxypropylphosphinic acid derivatives

The present invention relates to a process for the preparation of 3-amino-2-hydroxypropylphosphinic acid derivatives of the formula I, which are valuable pharmaceutical active ingredients and can be used, for example, as antidepressants. The process starts from O-ethyl phosphinates of the formula II into which, after silylation with hexamethyldisilazane, the 3-amino-2-hydroxypropyl moiety is introduced by reactions with epichlorohydrin and ammonia.