848780-28-9Relevant academic research and scientific papers
An approach to the synthesis of naphtho[b]furans from allyl bromonaphthyl ethers employing sequential photoinduced radical cyclization and dehydrohalogenation reactions
Suzuki, Yusuke,Okita, Yoshiki,Morita, Toshio,Yoshimi, Yasuharu
supporting information, p. 3355 - 3357 (2014/06/09)
A simple method has been developed for the efficient synthesis of naphtho[b]furans from allyl bromonaphthyl ethers. The approach utilizes a novel photochemical process involving sequential radical cyclization and dehydrohalogenation. Because light is a readily available, environmentally friendly reagent that produces no by-products, the new process serves as a green synthetic method.
Synthesis and biological evaluation of (±)-cryptotanshinone and its simplified analogues as potent CDC25 inhibitors
Huang, Wei Gang,Jiang, Ying Yan,Li, Qian,Li, Jia,Li, Jing Ya,Lu, Wei,Cai, Jun Chao
, p. 1863 - 1870 (2007/10/03)
(±)-Cryptotanshinone and its simplified analogues were synthesized via SmI2 promoted radical cyclization to construct the furan ring. Analogues 18 and 26 were identified as effective inhibitors of dual specificity protein phosphatase CDC25B which is a key enzyme for cell cycle progression, and they also inhibited growth in A-549 human lung cancer cell line.
