848784-30-5

Upstream product

• 848784-36-1 tert-butyl (-)-3-(p-tolylsulfinyl)methyl-5-phenylpentanoate 
• 104-53-0 3-phenyl-propionaldehyde 
• 848784-32-7 1-Chloro-4-phenyl-1-((R)-toluene-4-sulfinyl)-butan-2-ol 
• 848784-29-2 (R)-(Z)-1-chloro-4-phenyl-1-(p-tolylsulfinyl)-1-butene 
• 848784-35-0 tert-butyl (-)-[3-chloro(p-tolylsulfinyl)methyl]-5-phenylpentanoate 
• 1259929-89-9 tert-butyl (E)-3-methyl-5-phenyl-2-pentenoate 

Relevant academic research and scientific papers

Cobalt-Catalyzed Asymmetric 1,4-Reduction of β,β-Dialkyl α,β-Unsaturated Esters with PMHS

A cobalt-catalyzed asymmetric reduction of β,β-dialkyl α,β-unsaturated esters with polymethylhydrosiloxane (PMHS) was reported to deliver the corresponding esters containing a chiral trialkyl carbon center at β-position with up to 97 % yield and 98 % ee. The chiral tridentate ligand oxazoline iminopyridine (OIP) could perform well for the asymmetric reduction instead of chiral bidentate ligands. This operationally simple protocol shows a broad scope of substrates using one equivalent of readily available PMHS as a cheap and easy-to-handle reductive reagent.

Asymmetric synthesis of both enantiomers of esters and γ-lactones from optically active 1-chlorovinyl p-tolyl sulfoxides and lithium ester enolates with the formation of a tertiary or a quaternary carbon stereogenic center at the β-position

Treatment of optically active 1-chlorovinyl p-tolyl sulfoxides having two different substituents at the 2-position, which were synthesized from aldehydes or unsymmetrical ketones and (R)-(-)-chloromethyl p-tolyl sulfoxide in two or three steps, with the l