848785-45-5

Basic information

• Product Name: (S)-1-((S)-3-Benzyloxycarbonyl-3-tert-butoxycarbonylamino-propyl)-azetidine-2-carboxylic acid
• Synonyms: (S)-1-((S)-3-Benzyloxycarbonyl-3-tert-butoxycarbonylamino-propyl)-azetidine-2-carboxylic acid
• CAS NO: 848785-45-5
• Molecular Weight: 392.452
• Mol File: 848785-45-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-1-((S)-3-Benzyloxycarbonyl-3-tert-butoxycarbonylamino-propyl)-azetidine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-((S)-3-Benzyloxycarbonyl-3-tert-butoxycarbonylamino-propyl)-azetidine-2-carboxylic acid(848785-45-5)
• EPA Substance Registry System: (S)-1-((S)-3-Benzyloxycarbonyl-3-tert-butoxycarbonylamino-propyl)-azetidine-2-carboxylic acid(848785-45-5)

Safety Data

• Hazardous Substances Data: 848785-45-5(Hazardous Substances Data)

Upstream product

• 124994-66-7 (S)-benzyl-4-oxo-2-<<(1,1-dimethylethoxy)carbonyl>amino>butanoate 
• 2133-34-8 (2S)-azetidine-2-carboxylic acid 

Downstream Products

• 860795-17-1 (S)-1-{(S)-3-Benzyloxycarbonyl-3-[(S)-3-benzyloxycarbonyl-3-(tetrahydro-pyran-2-yloxy)-propylamino]-propyl}-azetidine-2-carboxylic acid 
• 848785-47-7 (S)-1-[(S)-3-Benzyloxycarbonyl-3-((S)-3-benzyloxycarbonyl-3-hydroxy-propylamino)-propyl]-azetidine-2-carboxylic acid 
• 74235-24-8 2'-deoxymugineic acid 
• 848785-46-6 (S)-1-((S)-3-Amino-3-benzyloxycarbonyl-propyl)-azetidine-2-carboxylic acid 

Relevant articles and documents

A short practical synthesis of 2′-deoxymugineic acid

A short and practical synthesis of 2′-deoxymugineic acid (DMA) has been developed via reductive alkylation with the aldehyde intermediates. No protection of azetidine-2-carboxylic acid was required and the presence of free carboxylic acid function facilitated purification by simple acid and base extractions. Furthermore, the intermediates were conveniently purified by HPLC due to the presence of chromophoric benzyl ester protecting group(s). Hydrogenolysis of the benzyl protecting groups in the final step furnished DMA in overall good yield.