848818-35-9

Basic information

• Product Name: 8-chloro-3-Methyl-2H-pyrazolo[4,3-c]quinolin-4(5H)-one
• Synonyms: 8-chloro-3-Methyl-2H-pyrazolo[4,3-c]quinolin-4(5H)-one
• CAS NO: 848818-35-9
• Molecular Formula: C11H8ClN3O
• Molecular Weight: 233.65372
• Mol File: 848818-35-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 8-chloro-3-Methyl-2H-pyrazolo[4,3-c]quinolin-4(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 8-chloro-3-Methyl-2H-pyrazolo[4,3-c]quinolin-4(5H)-one(848818-35-9)
• EPA Substance Registry System: 8-chloro-3-Methyl-2H-pyrazolo[4,3-c]quinolin-4(5H)-one(848818-35-9)

Safety Data

• Hazardous Substances Data: 848818-35-9(Hazardous Substances Data)

Upstream product

• 79075-07-3 3-acetyl-6-chloro-4-hydroxy-1H-quinolin-2-one 

Relevant articles and documents

Optimization of a pyrazoloquinolinone class of Chk1 kinase inhibitors

The development of 2,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-ones as inhibitors of Chk1 kinase is described. Introduction of a fused ring at the C7/C8 positions of the pyrazoloquinolinone provided an increase in potency while guidance from overlapping inhibitor bound Chk1 X-ray crystal structures contributed to the discovery of a potent and solubilizing propyl amine moiety in compound 52 (Chk1 IC50 = 3.1 nM).