848818-76-8Relevant academic research and scientific papers
Enzymatic Polyketide Chain Branching to Give Substituted Lactone, Lactam, and Glutarimide Heterocycles
Heine, Daniel,Bretschneider, Tom,Sundaram, Srividhya,Hertweck, Christian
, p. 11645 - 11649 (2014)
Polyketides typically result from head-to-tail condensation of acyl thioesters to produce highly functionalized linear chains. The biosynthesis of the phytotoxin rhizoxin, however, involves a polyketide synthase (PKS) module that introduces a δ-lactone ch
New 7,8-dihydro-1,6-naphthyridin-5(6h)-one-derivatives as PDE4 inhibitors
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Page/Page column 20, (2011/11/07)
New 7,8-dihydro-1,6-naphthyridin-5(6H)-one derivatives derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of the phosphodiesterase IV (PDE4).
CHK-1 INHIBITORS
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Page/Page column 213, (2010/02/11)
Disclosed are novel inhibitors of Chk-1 and methods of using the same for therapy.
