848821-60-3 Usage
Uses
Used in Organic Synthesis:
Pyrrolidine, 2-[bis(3,5-dimethylphenyl)[(trimethylsilyl)oxy]methyl]-, (2S)is utilized as a building block in organic synthesis for the creation of various complex organic compounds. Its unique structure and functional groups allow for versatile reactions and the formation of a wide range of products.
Used in Pharmaceutical Research:
In the pharmaceutical industry, Pyrrolidine, 2-[bis(3,5-dimethylphenyl)[(trimethylsilyl)oxy]methyl]-, (2S)serves as a key intermediate in the synthesis of pharmaceutical compounds. Its chiral nature and specific functional groups make it a valuable component in the development of new drugs with improved efficacy and selectivity.
Used in Protecting Group Chemistry:
The trimethylsilyloxy group in Pyrrolidine, 2-[bis(3,5-dimethylphenyl)[(trimethylsilyl)oxy]methyl]-, (2S)- is commonly used as a protecting group in organic chemistry. It is employed to prevent unwanted reactions or to facilitate specific transformations, ensuring the selective formation of desired products in complex synthetic pathways.
Used in Chiral Compound Synthesis:
Due to its (S)-stereoisomer classification, Pyrrolidine, 2-[bis(3,5-dimethylphenyl)[(trimethylsilyl)oxy]methyl]-, (2S)is used in the synthesis of chiral compounds. Chiral compounds are essential in various applications, including the development of enantiomerically pure drugs, which can exhibit different biological activities and reduce potential side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 848821-60-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,8,8,2 and 1 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 848821-60:
(8*8)+(7*4)+(6*8)+(5*8)+(4*2)+(3*1)+(2*6)+(1*0)=203
203 % 10 = 3
So 848821-60-3 is a valid CAS Registry Number.
848821-60-3Relevant academic research and scientific papers
Organocatalytic enantioselective α-hydroxymethylation of aldehydes: Mechanistic aspects and optimization
Boeckman, Robert K.,Biegasiewicz, Kyle F.,Tusch, Douglas J.,Miller, John R.
, p. 4030 - 4045 (2015/05/05)
Further studies of the direct enantioselective α-hydroxymethylation of aldehydes employing the α,α-diarylprolinol trimethylsilyl ether class of organocatalysts are described. This process has proven efficient for access to β-hydroxycarboxylic acids and δ-hydroxy-α,β-unsaturated esters from aldehydes in generally good yields, excellent enantioselectivity, and compatibility with a broad range of functional groups in the aldehyde. The goal of these studies was to identify the critical reaction variables that influence the yield and enantioselectivity of the α-hydroxymethylation process such as catalyst structure, pH of the medium, purity of the reactants and reagents particularly with respect to the presence of acidic impurities, and the nature of the buffer, along with the standard variables including solvent, time, temperature and mixing efficiency. The previously identified intermediate lactol has been further characterized and its reactivity examined. These studies have led to identification of the most critical variables translating directly into improved substrate scope, reproducibility, enantioselectivity, and yields.
Enantioselective organocatalyzed α sulfenylation of aldehydes
Marigo, Mauro,Wabnitz, Tobias C.,Fielenbach, Doris,Jorgensen, Karl Anker
, p. 794 - 797 (2007/10/03)
The facile elaboration of optically active α-sulfanyl-substituted aldehydes makes their direct preparation from unmodified aldehydes and 1-benzylsulfanyl-1,2,4-triazole particularly valuable. The substituted aldehydes are formed with excellent enantiosele
