848829-74-3

Upstream product

• 848829-70-9 6-(3-hydroxypropyl)-2,2-dimethyl-4H-1,3-dioxin-4-one 
• 86-93-1 1-Phenyl-1H-tetrazole-5-thiol 
• 5394-63-8 2,2,6-trimethyl-4H-1,3-dioxin-4-one 
• 848830-06-8 6-(but-3-enyl)-2,2-dimethyl-4H-1,3-dioxin-4-one 

Relevant academic research and scientific papers

Enantioselective total synthesis of cylindramide

Key steps in the convergent enantio-selective synthesis of the cytotoxic natural products (see structural formula) are tandem Michael addition/electrophilic trapping reactions, Sonogashira coupling, Julia-Kocienski olefination, and macro-cyclization. Form

Total synthesis and NMR investigations of cylindramide

Cylindramide (1) was built up from three components: a hydroxyornithine derivative 7, a tetrazolylsulfone 8, and a substituted pentalene subunit 9. Derivative 7 was prepared in a six-step reaction sequence involving the Wittig reaction and a Sharpless asy