84884-31-1

Basic information

• Product Name: 6-CHLORO-2-METHYL-3,4'-BIPYRIDINE-5-CARBONITRILE
• Synonyms: 6-CHLORO-2-METHYL-3,4'-BIPYRIDINE-5-CARBONITRILE
• CAS NO: 84884-31-1
• Molecular Formula: C₁₂H₈ClN₃
• Molecular Weight: 229.67
• Product Categories: Halides;Pyridines
• Mol File: 84884-31-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 155-157 °C(Solv: chloroform (67-66-3))
• Boiling Point: 380.3±42.0 °C(Predicted)
• Appearance: /
• Density: 1.32±0.1 g/cm3(Predicted)
• PKA: 2.43±0.10(Predicted)
• CAS DataBase Reference: 6-CHLORO-2-METHYL-3,4'-BIPYRIDINE-5-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-2-METHYL-3,4'-BIPYRIDINE-5-CARBONITRILE(84884-31-1)
• EPA Substance Registry System: 6-CHLORO-2-METHYL-3,4'-BIPYRIDINE-5-CARBONITRILE(84884-31-1)

Safety Data

• Hazardous Substances Data: 84884-31-1(Hazardous Substances Data)

Upstream product

• 78415-72-2 1,6-dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile 

Downstream Products

• 143951-73-9 2-(2-cyanophenyloxy)-6-methyl-5-pyridin-4-yl-3-pyridinecarbonitrile 
• 152633-64-2 6-<<(4-methoxyphenyl)methyl>amino>-2-methyl<3,4'-bipyridine>-3-carboxylic acid 
• 108611-20-7 6-(2-Amino-ethylamino)-2-methyl-[3,4']bipyridinyl-5-carbonitrile 
• 129090-35-3 6-amino-2-methyl<3,4'-bipyridine>-5-carbonitrile 

Relevant articles and documents

Imidazo[1,2-a]pyridines. III. Synthesis and bradycardic activity of new 5-imidazo[1,2-a]pyridin-6-ylpyridine derivatives

Structural modification of the cardiotonic agent, loprinone (E-1020, 1), suggested by data that it has a less positive chronotropic effect than milrinone (15), led us to find novel bradycardic agents that were structurally different from homoveratryl amine derivatives. Alkyl-oxy, -thio, and -amino derivatives at the 2-position of the pyridine ring of 1 produced bradycardic activity without a significant effect on blood pressure and myocardial contractility. Aryloxy analogues also decreased beart rate, and members with an electron-withdrawing group at the ortho position of the phenyl ring showed higher activity. Replacement of the imidazo[1,2-a]pyridine with pyridine resulted in diminished activity. The mechanism of bradycardic activity of these compounds seems to be direct action on the sinus node.