848852-15-3

Basic information

• Product Name: Benzamide, 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-5-[(E) -[[4-(methylamino)-4-oxobutoxy]imino]methyl]-
• CAS NO: 848852-15-3
• Molecular Formula: C21H22F3IN4O5
• Molecular Weight: 594.329
• Mol File: 848852-15-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzamide, 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-5-[(E) -[[4-(methylamino)-4-oxobutoxy]imino]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-5-[(E) -[[4-(methylamino)-4-oxobutoxy]imino]methyl]-(848852-15-3)
• EPA Substance Registry System: Benzamide, 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-5-[(E) -[[4-(methylamino)-4-oxobutoxy]imino]methyl]-(848852-15-3)

Safety Data

• Hazardous Substances Data: 848852-15-3(Hazardous Substances Data)

Upstream product

• 203916-59-0 2,3,4-trifluoro-5-iodobenzoic acid 
• 61079-72-9 2,3,4,-trifluorobenzoic acid 
• 848852-33-5 3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-5-vinylbenzoic acid 
• 848852-32-4 2,3,4-trifluoro-5-vinylbenzoic acid 
• 874100-39-7 3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-5-formyl-N-(2-hydroxyethoxy)benzamide 

Downstream Products

• 874101-00-5 CH4987655 

Relevant articles and documents

NOVEL CRYSTAL FORM OF 3,4-DIFLUORO-2-(2-FLUORO-4-IODO-PHENYL AMINO)-N-(2-HYDROXY-ETHOXY)-5-(3-OXO-[1,2]OXAZINAN-2-YLMETHYL)-BENZAMIDE

PROBLEM TO BE SOLVED: To provide an active pharmaceutical ingredient that is useful as MEK inhibitors and is stable physicochemically. SOLUTION: The present invention provides an educt I-type crystal of 3,4-difluoro-2-(2-fluoro-4-iodo-phenyl amino)-n-(2-hydroxy-ethoxy)-5-(3-oxo-[1,2]oxazinan-2-ylmethyl)-benzamide, having peaks with diffraction angles expressed by 2θ of 14.9, 16.9 and 23.1° (±0.2°) in a powder X-ray diffraction pattern measured using Cu Kα(1.54060?) as an X-ray source. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT

NOVEL 4-PHENYLAMINO-BENZALDOXIME DERIVATIVE AND USE THEREOF AS MEK INHIBITOR

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