848853-68-9Relevant academic research and scientific papers
A preparatively convenient ligand-free catalytic PEG 2000 suzuki-miyaura coupling
Razler, Thomas M.,Hsiao, Yi,Qian, Feng,Fu, Ruiling,Khan, Rana Kashif,Doubleday, Wendel
, p. 1381 - 1384 (2009)
A ligand-free Suzuki-Miyaura reaction for the cross-coupling of aryl and heteroaryl bromides with aryl and heteroarylboronic acids has been developed utilizing catalytic polyethylene glycol 2000 (PEG 2000). This preparatively convenient system afforded the corresponding cross-coupled products in good to excellent isolated yields after a simple aqueous workup. Transmission electron microscopy (TEM) analysis of the Pd-PEG 2000 catalyst system revealed in situ-generated palladium nanoparticles after only 1 min of reaction.
