848940-03-4Relevant articles and documents
Synthesis of mono-glucose-branched cyclodextrins with a high inclusion ability for doxorubicin and their efficient glycosylation using Mucor hiemalis endo-β-N-acetylglucosaminidase
Yamanoi, Takashi,Yoshida, Naomichi,Oda, Yoshiki,Akaike, Eri,Tsutsumida, Maki,Kobayashi, Natsumi,Osumi, Kenji,Yamamoto, Kenji,Fujita, Kiyotaka,Takahashi, Keiko,Hattori, Kenjiro
, p. 1009 - 1013 (2005)
The mono-glucose-branched cyclodextrins having an appropriate spacer between the β-cyclodextrin and a glucose moiety were synthesized from β-cyclodextrin and arbutin. They had the significantly high association constants for doxorubicin, the anticancer agent, in the range of 10 5-106 M-1, and worked as highly reactive glycosyl acceptors for the transglycosylation reaction by endo-β-N- acetylglucosaminidase of Mucor hiemalis to produce sialo-complex type oligosaccharide-branched cyclodextrins in the high yields of 65-67%.