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Usage

Uses

Used in Pharmaceutical Synthesis:
4-Cyano-2-Methylphenylboronic acid, pinacol ester is used as a key intermediate in the synthesis of pharmaceuticals for its ability to form essential carbon-carbon and carbon-heteroatom bonds. Its reactivity in cross-coupling reactions facilitates the creation of complex molecular structures required for drug development.
Used in Agrochemical Production:
In the agrochemical industry, 4-Cyano-2-Methylphenylboronic acid, pinacol ester is used as a building block for the synthesis of various agrochemicals. Its role in forming crucial bonds allows for the development of effective compounds used in crop protection and pest management.
Used in Materials Science:
4-Cyano-2-Methylphenylboronic acid, pinacol ester is employed as a component in the synthesis of advanced materials in materials science. Its ability to form stable bonds contributes to the development of new materials with specific properties for various applications, such as in electronics, coatings, and composites.
Overall, 4-Cyano-2-Methylphenylboronic acid, pinacol ester is a versatile chemical compound with a broad range of applications across different industries, primarily due to its reactivity in organic synthesis and its role in Suzuki-Miyaura cross-coupling reactions.

Upstream product

• 41963-20-6 4-bromo-3-methylbenzonirtile 
• 73183-34-3 bis(pinacol)diborane 
• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 313546-18-8 (4-cyano-2-methylphenyl)boronic acid 

Downstream Products

• 1030832-26-8 3-(bromomethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 
• 1352344-91-2 C₂₃H₃₇FN₂O₅ 
• 1312099-47-0 4-(4-bromothiophen-3-yl)-3-methylbenzonitrile 
• 1312099-51-6 (E)-ethyl 3-(4-(4-cyano-2-methylphenyl)thiophen-3-yl)acrylate 
• 1312099-53-8 ethyl 3-(4-(4-cyano-2-methylphenyl)thiophen-3-yl)propanoate 
• 1312099-55-0 ethyl 3-(5-bromo-4-(4-cyano-2-methylphenyl)thiophen-3-yl)propanoate 
• 1312099-57-2 3-(4-(4-cyano-2-methylphenyl)-5-(4-methoxyphenyl)thiophen-3-yl)propanoic acid 
• 1353572-39-0 3-(4-(4-carbamoyl-2-methylphenyl)-5-(4-methoxyphenyl)thiophen-3-yl)propanoic acid 
• 15777-70-5 4-hydroxy-3-methylbenzonitrile 

Relevant academic research and scientific papers

Phosphorescent κ3-(N^C^C)-Gold(III) Complexes: Synthesis, Photophysics, Computational Studies and Application to Solution-Processable OLEDs

Efficient OLED devices have been fabricated using organometallic complexes of platinum group metals. Still, the high material cost and low stability represent central challenges for their application in commercial display technologies. Based on its innate

SAR Exploration of Tight-Binding Inhibitors of Influenza Virus PA Endonuclease

Significant efforts have been reported on the development of influenza antivirals including inhibitors of the RNA-dependent RNA polymerase PA N-terminal (PAN) endonuclease. Based on recently identified, highly active metal-binding pharmacophore

2-METHYL-QUINAZOLINES

The present invention describes 2-methyl-quinazoline compounds of general formula (I), methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions. The 2-methyl substituted quinazoline compounds of general formula(I) effectively and selectively inhibit the Ras-Sos interaction without significantly targeting the EGFR receptor. They are therefore useful for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, such as cancer as a sole agent or in combination with other active ingredients.

Visible-Light Photoredox Borylation of Aryl Halides and Subsequent Aerobic Oxidative Hydroxylation

Efficient and practical visible-light photoredox borylation of aryl halides and subsequent aerobic oxidative hydroxylation were developed. The protocols use readily available aryl halides and bis(pinacolato)diboron as the starting materials, fac-Ir(ppy)3 as the photocatalyst, and corresponding arylboronic esters and phenols were obtained in good yields. The methods show some advantages including simple equipment, mild conditions, easy operation, and wide substrate scope. Therefore, they should provide a valuable strategy for chemical transformations.

Enantioenriched synthesis of Escitalopram using lithiation-borylation methodology

The asymmetric synthesis of Escitalopram has been completed using a lithiation-borylation reaction as the key step. Suitably functionalized enantioenriched carbamate (er 98:2) and boronic ester coupling partners were prepared and following deprotonation with s-BuLi and borylation, the tertiary alcohol was obtained in 42% yield and 93:7 er. The lithiation-borylation reaction was found to tolerate nitrile, benzylic alcohol and N-Boc functionalities. The tertiary alcohol was converted to Escitalopram in three further steps.

OXIDATION RESISTANT INDICATOR MOLECULES

Compounds having enhanced oxidation stability are disclosed. The compounds have an aryl boronic acid residue having one or more electron withdrawing groups on the aromatic moiety which contains the boronic acid residue, such that the molecule has enhanced

2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS

The present invention provides selective 5-HT7 receptor antagonist compounds of Formula I and their use in the treatment of migraine, persistent pain, and anxiety: where A and B are each independently C(H)= or N=, provided that at least one of A and B is -N=, n is 1-3, m is 0-3, and R14 are as defined herein.

SUBSTITUTED TRIAZOLE DERIVATIVES AS OXYTOCIN ANTAGONISTS

The present invention relates to a class of substituted 1,2,4-triazoles of formula (I) with activity as oxytocin antagonists, uses thereof, processes for the preparation thereof and compositions containing, said, inhibitors. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction, particularly premature ejaculation (P.E.).